The DNA breakthrough investigators desperately needed just slipped through their fingers. Mystery genetic material found on a critical glove discovered near Nancy Guthrie’s Arizona home has produced zero matches in the FBI’s massive database, officials confirmed Tuesday. This isn’t just a minor setback — it’s a crushing blow to the investigation into the disappearance of “Today” show host Savannah Guthrie’s mother.
Here’s what makes this development so devastating: The black glove was found just 2 miles from Nancy’s million-dollar Tucson home and appears identical to one worn by a masked intruder captured on surveillance footage before her abduction. Pima County Sheriff Chris Nanos delivered the grim news that the Combined DNA Index System turned up absolutely nothing. But it gets worse — separate DNA evidence collected inside Nancy’s house also failed to match any records in the FBI database.
The investigation is now drowning in information overload. Local police and federal agents are scrambling to process between 40,000 and 50,000 leads while their most promising physical evidence has led nowhere. Authorities collected more than a dozen gloves from the scene near the main highway through the upscale Catalina Foothills neighborhood, but most turned out to be contamination from searchers themselves. The few remaining pieces of evidence represent their last hope for a DNA breakthrough.
What’s particularly frustrating for investigators is how quickly modern DNA analysis works — the FBI can run samples through CODIS and get results within 24 hours. The system cross-references crime scene evidence with DNA profiles from convicted violent criminals and felons. Nancy Guthrie vanished on January 31st, and despite all the technological advantages and massive investigative resources, authorities still have zero suspects or persons of interest.
Thank you for visiting